9a, d, e), thus confirming the importance and generalization of PGE2/COX2 signalling during development of chemoresistance, while other metabolites of the arachidonic acid pathway may also be involved

9a, d, e), thus confirming the importance and generalization of PGE2/COX2 signalling during development of chemoresistance, while other metabolites of the arachidonic acid pathway may also be involved. repopulation can be abrogated by a PGE2-neutralizing antibody and celecoxib drug-mediated blockade of PGE2 signalling. administration of the cyclooxygenase-2 (COX2) inhibitor celecoxib effectively abolishes a PGE2- and … Read more

(c,f) Backbone generation (c) and elimination (f) rates over 2-day intervals in wild-type or KO mice with a glass window reared in NC (wild-type: 12 intervals, five cells, five mice, 1526 spines; KO: 14 intervals, six cells, five mice, 2393 spines), KO mice raised in EE conditions (nine intervals, five cells, five mice, 1983 spines), KO mice that received intraperitoneal MK801 (10 intervals, five cells, four mice, 1233 spines), GM6001 (10 intervals, five cells, three mice, 1141 spines), or minocycline through drinking water (eight intervals, five cells, five mice, 1090 spines), in addition to mice that received the interface device with infusion of APV+ iVDCC (eight intervals, five cells, three mice, 996 spines)

(c,f) Backbone generation (c) and elimination (f) rates over 2-day intervals in wild-type or KO mice with a glass window reared in NC (wild-type: 12 intervals, five cells, five mice, 1526 spines; KO: 14 intervals, six cells, five mice, 2393 spines), KO mice raised in EE conditions (nine intervals, five cells, five mice, 1983 spines), … Read more

Whiskers were drawn between the highest and lowest data points within 1

Whiskers were drawn between the highest and lowest data points within 1.5 interquartile range (IQR) from the upper or lower quartile. as well as reduced histone H3K27 acetylation in several key glycolysis Kdr genes. Furthermore, deficiency sensitizes MEFs to 2-deoxy-D-glucose, a competitive inhibitor of glycolysis, to induce cell blebbing. Activated Rapgef1, a Crk/Crkl-downstream effector, rescues … Read more