Immunogenetics
Immunogenetics. MoAbs bind the amino-terminal third of GAD65, but instead target the carboxy-terminal two-thirds of GAD65. Amino acids 270C359 (IDDM-E1) are targeted by one APS2 IgG antibody and MICA-4, while two additional APS2 IgG antibodies, MICA-2 and MICA-3, target amino acids 443C585 (IDDM-E2). Using GAD65/67 chimera that span the IDDM-E2 region, we found that MICA-2 … Read more