The cytotoxicity of Rituximab/saporin-S6 was augmented by the co-administration with the chemotherapy drug fludarabine, leading to the complete elimination of the malignant population [78]
The cytotoxicity of Rituximab/saporin-S6 was augmented by the co-administration with the chemotherapy drug fludarabine, leading to the complete elimination of the malignant population [78]. The anti-hTfR IgG3-Av, consisting of a mouse/human chimeric IgG3 genetically fused to chicken avidin, was conjugated to biotinylated saporin-S6. intracellular routing and the pathogenetic mechanisms of the cell damage, are reported. … Read more