RvE1 regulates P2Y12signaling in a ChemR23-dependant manner
RvE1 regulates P2Y12signaling in a ChemR23-dependant manner. receptor, human ChemR23 (present on human platelets), addition of RvE1 (0.1nM-10.0nM) blocked ADP signals (IC50~1.61011M) in P2Y12-ChemR23-expressing cells compared to mock transfections. == Conclusions == These results demonstrate that RvE1s regulatory actions (i.e reducing ADP-stimulated P-selectin mobilization and actin polymerization) are hChemR23-dependent. Moreover, they document specific platelet actions … Read more