J. Oaz1 mediate renal tubular uptake of IS in basolateral membrane, were markedly downregulated by renal I/R, but restored by SULT inhibitors. Our results suggest that renal accumulation of IS in ischemic AKI induces oxidative stress and downregulation of organic anion transporters resulting in kidney damage, which could be restored to some extent by inhibiting … Read more
Ravindra K. 1,4-naphthoquinones, which involves redox cycling and nucleophilic adduct formation, and it suggests possible routes of synthesis of the non-toxic inhibitor. and plant genera and have a variety of biological activities (3). Our laboratory previously reported that one of the 1,4-naphthoquinones, plumbagin, is a potent inhibitor of the KAT p300. Plumbagin specifically inhibits p300-mediated … Read more