The addition of miRT-126 to myeloid-specific FVIII expression prevents anti-FVIII antibody generation
The addition of miRT-126 to myeloid-specific FVIII expression prevents anti-FVIII antibody generation. (inhibitors). Moreover, inhibitors were eradicated in FVIII pre-immune mice through a regulatory T cell-dependent mechanism. In conclusion, targeting FVIII expression to LSECs and myeloid cells by using LVs with cell-specific promoter minimized off-target expression and immune responses. Therefore, at least for some transgenes, … Read more