It is possible that serum IgG anti-endotoxin antibody has fallen to its nadir by the time of admission (1 to 2 2 wk) and that it may be rising subsequently, earlier in patients without organ failure and later and slowly in patients with organ failure who did not succumb to their organ failure. and IgM anti-endotoxin levels and LMR at baseline and at D7 among patients with organ failure, infection and mortality. Interpretation & conclusions: Our findings showed that serum IgG and IgM anti-endotoxin titres and LMR at admission and at day 7 were not associated with organ failure, infection, and death of patients with AP. test/one-way Anova followed by comparison using Bonferroni correction. Skewed continuous variables were compared among the groups by Wilcoxon rank-sum/Kruskal-Wallis test followed by multiple comparisons using Dunn’s test with Bonferroni correction. Results A total of 204 patients of AP who had undergone either serum anti-endotoxin antibody testing or LMR were included, of whom 180 had severe disease. Males constituted eight (33.3%) patients of mild AP, 88 (63.3%) of SAP in the first week and 25 (61%) patients of SAP presenting beyond the first week of illness ( 0.05). Table III Markers of endotoxaemia and intestinal permeability in patients with severe acute pancreatitis with organ failure (n=180) thead th align=”left” rowspan=”3″ colspan=”1″ Variables /th th align=”center” colspan=”2″ rowspan=”1″ Any organ failure (n=110) /th th align=”center” colspan=”2″ rowspan=”1″ No organ failure (n=70) /th th align=”center” colspan=”2″ rowspan=”1″ hr / /th th align=”center” colspan=”2″ rowspan=”1″ hr Lincomycin hydrochloride (U-10149A) / /th th align=”center” rowspan=”1″ colspan=”1″ n /th Lincomycin hydrochloride (U-10149A) th align=”center” rowspan=”1″ colspan=”1″ /th th align=”center” rowspan=”1″ colspan=”1″ n /th th align=”center” rowspan=”1″ colspan=”1″ /th /thead IgG0, GMU/ml89140 (4-1600)61180 (4-1760)IgG7, GMU/ml75140 (18-1600)55174 (2-1640)IgM0, MMU/ml9452 (2-178)6144 (4-180)IgM7, MMU/ml8055 (7-801)5350 (8-350)LMR0860.1178 (0.012-3)500.1535 (0.008-1.29)LMR7590.124 (0.009-5)400.1565 (0.009-1.25) Open in a separate window Values are expressed as median (minimum-maximum). LMR, lactulose-mannitol ratio; Suffix 0, test done at day 0 of admission; Suffix 7, test done at day 7 of admission. GMU, IgG median-unit; MMU, IgM median-unit In SAP patients (n=180), at baseline, the median IgG anti-endotoxin titre was 140 (4-1600) GMU/ml among patients with organ failure (n=110) and 180 (4-1760) GMU/ml among patients without organ failure (n=70), while at D7, the median IgG anti-endotoxin antibody titre was 140 (18-1600) GMU/ml in patients with organ failure compared to 174 (2-1640) GMU/ml among patients without organ failure ( em P /em 0.05). There was no difference in LMR at D0 and D7 between patients who developed organ failure and those who Lincomycin hydrochloride (U-10149A) did not. em Anti-endotoxin antibody titres and LMR with infection /em : Table IV shows anti-endotoxin antibody titres and LMR among patients of SAP who developed an infection. There was no significant difference in anti-endotoxin IgG and IgM and LMR among patients who developed infection subsequently compared to those who did not develop an infection. Table IV Markers of endotoxaemia and intestinal permeability in patients with severe acute pancreatitis in relation to infection (n=180) thead th align=”left” rowspan=”3″ colspan=”1″ Variables /th th align=”center” colspan=”2″ rowspan=”1″ Any infection (n=44) /th th align=”center” colspan=”2″ rowspan=”1″ No infection (n=136) /th th align=”center” colspan=”2″ rowspan=”1″ hr / /th th align=”center” colspan=”2″ rowspan=”1″ hr / /th th align=”center” rowspan=”1″ colspan=”1″ n /th Rabbit Polyclonal to ARC th align=”center” rowspan=”1″ colspan=”1″ /th th align=”center” rowspan=”1″ colspan=”1″ n /th th align=”center” rowspan=”1″ colspan=”1″ /th /thead IgG0, GMU/ml37168 (4-840)113160 (4-1760)IgG7, GMU/ml31214 (20-1160)99160 (2-1640)IgM0, MMU/ml3849 (2-162)11750 (2-180)IgM7, MMU/ml3757 (20-350)9650 (7-801)LMR0310.117 (0.0125-3)1050.132 (0.008-3)LMR7210.124 (0.015-5)780.149 (0.009-2.6) Open in a separate window Values are expressed as median (minimum-maximum). LMR, lactulose-mannitol ratio; Suffix 0, test done at day 0 of admission; Suffix 7, test done at day 7 of admission. GMU, IgG median-unit; MMU, IgM median-unit em Anti-endotoxin antibody titres and LMR with mortality /em : Table V shows the association of anti-endotoxin antibody titres and LMR with mortality among Lincomycin hydrochloride (U-10149A) patients with SAP. There was no significant difference in anti-endotoxin antibody titres and LMR in non-survivors compared to survivors. Table V Markers of endotoxaemia and intestinal permeability in patients with severe acute pancreatitis in relation to mortality (n=180) thead th align=”left” rowspan=”3″ colspan=”1″ Variables /th th align=”center” colspan=”2″ rowspan=”1″ Survivors (n=149) /th th align=”center” colspan=”2″ rowspan=”1″ Non-survivors (n=31) /th th align=”center” colspan=”2″ rowspan=”1″ hr / /th th align=”center” colspan=”2″ rowspan=”1″ hr / /th th align=”center” rowspan=”1″ colspan=”1″ n /th th align=”center” rowspan=”1″ colspan=”1″ /th th align=”center” rowspan=”1″ colspan=”1″ n /th th align=”center” rowspan=”1″ colspan=”1″ /th /thead IgG0, GMU/ml126160 (4-1760)24200 (28-1600)IgG7, GMU/ml113160 (2-1640)17262 (32-1600)IgM0, MMU/ml12950 (2-180)2656 (2-160)IgM7, MMU/ml11555 (7-801)1860 (20-106)LMR01120.143 (0.008-3)240.106 (0.020-3)LMR7860.149 (0.009-5)130.133 (0.015-1.9) Open in a separate window Values are expressed as median (minimum-maximum). LMR, lactulose-mannitol ratio; Suffix 0, test done at day 0 of admission; Suffix 7, test done at day 7 of admission. GMU, IgG median-unit; MMU, IgM median-unit The proportion of patients with alcohol as aetiology was similar between various groups (infection vs. no infection; mortality vs. no mortality; organ failure vs. no organ failure). Discussion In this secondary pooled data analysis, a total of.